Publications
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2024
Pandiloski N, Horváth V, Karlsson O, Koutounidou S, Dorazehi F, Christoforidou G, Matas-Fuentes J, Gerdes P, Garza R, Jönsson ME, Adami A, Atacho DAM, Johansson JG, Englund E, Kokaia Z, Jakobsson J, Douse CH.
DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor. OPEN ACCESS
Nat Commun. 2024 Aug 30
Gustavsson EK, Sethi S, Gao Y, Brenton JW, García-Ruiz S, Zhang D, Garza R, Reynolds RH, Evans JR, Chen Z, Grant-Peters M, Macpherson H, Montgomery K, Dore R, Wernick AI, Arber C, Wray S, Gandhi S, Esselborn J, Blauwendraat C, Douse CH, Adami A, Atacho DAM, Kouli A, Quaegebeur A, Barker RA, Englund E, Platt F, Jakobsson J, Wood NW, Houlden H, Saini H, Bento CF, Hardy J, Ryten M.
The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1. OPEN ACCESS
Sci Adv. 2024 Jun 28
Vivien Horváth, Raquel Garza, Marie E. Jönsson, Pia A. Johansson, Anita Adami, Georgia Christoforidou, Ofelia Karlsson, Laura Castilla Vallmanya, Symela Koutounidou, Patricia Gerdes, Ninoslav Pandiloski, Christopher H. Douse & Johan Jakobsson
Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease OPEN ACCESS
Nature structural & molecular biology. Published: 04 June 2024
2023
Raquel Garza, Yogita Sharma, Diahann A.M. Atacho, Arun Thiruvalluvan, Sami Abu Hamdeh, Marie E. Jönsson, Vivien Horvath, Anita Adami, Martin Ingelsson, Patric Jern, Molly Gale Hammell, Elisabet Englund, Agnete Kirkeby, Johan Jakobsson, Niklas Marklund
Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia OPEN ACCESS
Cell Reports, Available online 14 November 2023.
Raquel Garza, Diahann A M Atacho, Anita Adami, Patricia Gerdes, Meghna Vinod, PingHsun Hsieh, Ofelia Karlsson, Vivien Horvath, Pia A Johansson, Ninoslav Pandiloski, Jon Matas-Fuentes, Annelies Quaegebeur, Antonina Kouli, Yogita Sharma, Marie E Jönsson, Emanuela Monni, Elisabet Englund, Evan E Eichler, Molly Gale Hammell, Roger A Barker, Zaal Kokaia, Christopher H Douse, Johan Jakobsson
LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification OPEN ACCESS
Sci Adv. 2023 Nov 3
Soophie Olfat, Kärt Mätlik, Jaakko J. Kopra, Daniel R. Garton, Vilma H. Iivanainen, Dipabarna Bhattacharya, Johan Jakobsson, T. Petteri Piepponen, and Jaan-Olle Andressoo
Increased Physiological GDNF Levels Have No Effect on Dopamine Neuron Protection and Restoration in a Proteasome Inhibition Mouse Model of Parkinson’s Disease OPEN ACCESS
eNeuro. 2023 Feb; 10(2)
2022
Janelle Drouin-Ouellet, Emilie M Legault, Fredrik Nilsson, Karolina Pircs, Julie Bouquety, Florence Petit, Shelby Shrigley, Marcella Birtele, Maria Pereira, Petter Storm, Yogita Sharma, Andreas Bruzelius, Romina Vuono, Malin Kele, Thomas B Stoker, Daniella Rylander Ottosson, Anna Falk, Johan Jakobsson, Roger A Barker, Malin Parmar
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease OPEN ACCESS
Stem Cell Reports, 2022 Oct 11
Serena Petry, Rémi Keraudren, Behnaz Nateghi, Andréanne Loiselle, Karolina Pircs, Johan Jakobsson, Chantelle Sephton, Mélanie Langlois, Isabelle St-Amour, Sébastien S Hébert
Widespread alterations in microRNA biogenesis in human Huntington's disease putamen OPEN ACCESS
Acta Neuropathol Commun. 2022 Jul 22
Kärt Mätlik, Daniel R. Garton, Ana R. Montaño-Rodríguez, Soophie Olfat, Feride Eren, Laoise Casserly, Anastasios Damdimopoulos, Anne Panhelainen, L. Lauriina Porokuokka, Jaakko J. Kopra, Giorgio Turconi, Nadine Schweizer, Erika Bereczki, Fredrik Piehl, Göran Engberg, Simon Cervenka, T. Petteri Piepponen, Fu-Ping Zhang, Petra Sipilä, Johan Jakobsson, Carl M. Sellgren, Sophie Erhardt & Jaan-Olle Andressoo
Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophreniaOPEN ACCESS
Mol Psychiatry. 2022 May 26.
Pia Annette Johansson, Anita Adami, Johan Jakobsson
CRISPRi-mediated transcriptional silencing in iPSCs for the study of human brain development OPEN ACCESS
STAR Protoc. 2022 Apr 13
Karolina Pircs, Roger A Barker, Johan Jakobsson
Hunting out the autophagic problem in Huntington disease
Autophagy. 2022 May 3
Johan Jakobsson, Michelle Vincendeau
SnapShot: Human endogenous retroviruses
Cell. Volume 185, Issue 2, 20 January 2022, Pages 400-400.
2021
Karolina Pircs, Janelle Drouin-Ouellet, Vivien Horváth, Jeovanis Gil, Melinda Rezeli, Raquel Garza, Daniela A. Grassi, Yogita Sharma, Isabelle St-Amour, Kate Harris, Marie E. Jönsson, Pia A. Johansson, Romina Vuono, Shaline V. Fazal, Thomas Stoker, Bob A. Hersbach, Kritika Sharma, Jessica Lagerwall, Stina Lagerström, Petter Storm, Sébastien S. Hébert, György Marko-Varga, Malin Parmar, Roger A. Barker, Johan Jakobsson
Distinct subcellular autophagy impairments in induced neurons from Huntington’s disease patients OPEN ACCESS
Brain, 22 December 2021
Johansson P.A., Per Ludvik Brattås P.L., Douse Ch.H., Hsieh PH, Adami A, Pontis J, Grassi D, Garza R, Sozzi E, Cataldo R, Jönsson M.E., Atacho D.A.M., Pircs K, Eren F, Sharma Y, Johansson J, Fiorenzano A, Parmar M, Fex M, Trono D, Eichler E.E., Jakobsson J.
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development OPEN ACCESS
Cell Stem Cell, 7 oktober 2021
Jönsson ME, Garza R, Sharma Y, Petri R, Södersten E, Johansson JG, Johansson PA, Atacho DA, Pircs K, Madsen S, Yudovich D, Ramakrishnan R, Holmberg J, Larsson J, Jern P, Jakobsson J.
Activation of endogenous retroviruses during brain development causes an inflammatory response. OPEN ACCESS
EMBO J. 2021 Mar 1
Klawonn A.M, Fritz M, Castany S, Pignatelli M, Canal C, Similä F, Tejeda H.A, Levinsson J, Jaarola M, Jakobsson J, Hidalgo J, Heilig M, Bonci A, Engblom D
Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons
Immunity. 2021 Jan 13
2020
Jönsson M E, Garza R, Johansson P A, Jakobsson J
Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders OPEN ACCESS
Trends in Genetics. June 1st, 2020
Brattås PL, Hersbach BA, Madsen S, Petri R, Jakobsson J, Pircs K
Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease. OPEN ACCESS
Autophagy. 2020 May 6:1-14
Butler CR, Boychuk JA, Pomerleau F, Alcala R, Huettl P, Ai Y, Jakobsson J, Whiteheart SW, Gerhardt GA, Smith BN, Slevin JT.
Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics.
Epilepsy Res. 2020 Jan.
2019
Grassi DA, Brattås PL, Jönsson ME, Atacho D, Karlsson O, Nolbrant S, Parmar M, Jakobsson J.
Profiling of lincRNAs in human pluripotent stem cell derived forebrain neural progenitor cells. OPEN ACCESS
Heliyon. 2019 Dec 31
Sabelström H, Petri R, Shchors K, Jandial R, Schmidt C, Sacheva R, Masic S, Yuan E, Fenster T, Martinez M, Saxena S, Nicolaides TP, Ilkhanizadeh S, Berger MS, Snyder EY, Weiss WA, Jakobsson J, Persson AI.
Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness. OPEN ACCESS
Cell Rep. 2019 Aug 20.
Jönsson ME, Ludvik Brattås P, Gustafsson C, Petri R, Yudovich D, Pircs K, Verschuere S, Madsen S, Hansson J, Larsson J, Månsson R, Meissner A, Jakobsson J.
Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors. OPEN ACCESS
Nat Commun. 2019 Jul 18
Petri R, Brattås PL, Sharma Y, Jönsson ME, Pircs K, Bengzon J, Jakobsson J.
LINE-2 transposable elements are a source of functional human microRNAs and target sites. OPEN ACCESS
PLoS Genet. 2019 Mar 13
2018
Kutsche LK, Gysi DM, Fallmann J, Lenk K, Petri R, Swiersy A, Klapper SD, Pircs K, Khattak S, Stadler PF, Jakobsson J, Nowick K, Busskamp V.
Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis. OPEN ACCESS
Cell Syst. 2018 Sep 28
Pircs K, Petri R, Jakobsson J.
Crosstalk between MicroRNAs and Autophagy in Adult Neurogenesis: Implications for Neurodegenerative Disorders. OPEN ACCESS
Brain Plast. 2018 Aug 10
Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Hult Lundh S, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA, Jakobsson J.
Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation OPEN ACCESS
Cell Reports 24, 1397–1406, August 7, 2018
Grassi DA, Jönsson ME, Brattås PL, Jakobsson J.
TRIM28 and the control of transposable elements in the brain
Brain Res. 2018 Mar 6.
Burmeister, J.J., Pomerleau, F., Quintero, J.E., Huettl, P., Ai, Y., Jakobsson, J., Lundblad, M., Heuer, A., Slevin, J.T., Gerhardt, G.A.
In vivo electrochemical studies of optogenetic control of glutamate signaling measured using enzyme-based ceramic microelectrode arrays.
NeuromethodsVolume 130, 2018, Pages 327-351
Petri R, Jakobsson J
Identifying miRNA Targets Using AGO-RIPseq
Methods Mol Biol. 2018;1720:131-140
2017
Drouin-Ouellet J, Pircs K, Barker RA, Jakobsson J, Parmar M.
Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned? OPEN ACCESS
Front Neurosci. 2017 Sep 28
Brawek B, Liang Y, Savitska D, Li K, Fomin-Thunemann N, Kovalchuk Y, Zirdum E, Jakobsson J, Garaschuk O
A new approach for ratiometric in vivo calcium imaging of microglia. OPEN ACCESS
Sci Rep. 2017 Jul 20;7(1):6030
Drouin-Ouellet J, Lau S, Brattås PL, Rylander Ottosson D, Pircs K, Grassi DA, Collins LM, Vuono R, Andersson Sjöland A, Westergren-Thorsson G, Graff C, Minthon L, Toresson H, Barker RA, Jakobsson J, Parmar M
REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways. OPEN ACCESS
EMBO Mol Med. 2017 Jun 23.
Petri R, Pircs K, Jönsson ME, Åkerblom M, Brattås PL, Klussendorf T, Jakobsson J
let‐7 regulates radial migration of new‐born neurons through positive regulation of autophagy
EMBO Journal. 23 March 2017.
Alcacer C, Andreoli L, Sebastianutto I, Jakobsson J, Fieblinger T, Cenci MA
Chemogenetic stimulation of striatal projection neurons modulates responses to Parkinson's disease therapy OPEN ACCESS
J Clin Invest. 2017 Jan 23.
Brattås PL, Jönsson ME, Fasching L, Nelander Wahlestedt J, Shahsavani M, Falk R, Falk A, Jern P, Parmar M, Jakobsson J
TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells OPEN ACCESS
Cell Reports. January 3rd, 2017
2016
Malmevik J, Petri R, Knauff P, Brattås PL, Åkerblom M, Jakobsson J
Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons.
Sci Rep. 2016 Jan 27;6:19879
2015
Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Björk Wilhelms D, Lazarus M, Löfberg A, Jaarola M, Örtegren Kugelberg U, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Rodriguez Parkitna J, Saper CB, Blomqvist A, Engblom D
Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice OPEN ACCESS
Journal of Clinical Investigation. 2015 Dec 21. pii: 83844.
Jönsson ME, Nelander Wahlestedt J, Åkerblom M, Kirkeby A, Malmevik J, Brattaas PL, Jakobsson J, Parmar M
Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor OPEN ACCESS
Development. 2015 Sep 15;142(18):3166-77.
Malmevik J, Petri R, Klussendorf T, Knauff P, Åkerblom M, Johansson J, Soneji S, Jakobsson J
Identification of the miRNA targetome in hippocampal neurons using RIP-seq OPEN ACCESS
Scientific Reports 5, Article number: 12609 (2015). Published online: 28 July 2015
Grealish S, Heuer A, Cardoso T, Kirkeby A, Jönsson M, Johansson J, Björklund A, Jakobsson J, Parmar M
Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons OPEN ACCESS
Stem Cell Reports. 2015 May 20
Fasching L, Kapopoulou A, Sachdeva R, Petri R, Jönsson M E, Männe C, Turelli P, Jern P, Cammas F, Trono D, Jakobsson J
TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells OPEN ACCESS
Cell Reports, 2015 Jan 6;10(1):20-8
2014
Lau S, Ryllander Ottosson D, Jakobsson J, Parmar M
Direct Neural Conversion from Human Fibroblasts Using Self-Regulating and Nonintegrating Viral Vectors OPEN ACCESS
Cell Reports, Volume 9, Issue 5, p1673–1680, 11 December 2014
Åkerblom M, Petri R, Sachdeva R, Klussendorf T, Mattsson B, Gentner B, Jakobsson J
microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons OPEN ACCESS
Development. March 5, 2014
2013
Malmevik J, Åkerblom M, Jakobsson J
microRNA and Neurodegenarative diseases
book chapter in: microRNAs in Toxicology and Medicine, editor Saura C. Sahu, October 2013
Petri R, Malmevik J, Fasching L, Åkerblom M, Jakobsson J
miRNAs in brain development
Experimental Cell Research. 2013 Oct 4
Åkerblom M, Jakobsson J
MicroRNAs as Neuronal Fate Determinants
Neuroscientist. 2013 Jul 22.
Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J, Björklund A
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
PNAS April 22, 2013
Åkerblom M, Sachdeva R, Quintino L, Elgstrand Wettergren E, Chapman K Z, Manfre G, Lindvall O, Lundberg C, Jakobsson J
Visualization and genetic modification of resident brain microglia using lentiviral vectors regulated by microRNA-9
Nature Communications 4, Article number: 1770. 23 April 2013.
Torper O, Pfisterer U, Wolf DA, Pereira M, Lau S, Jakobsson J, Björklund A, Grealish S, Parmar M
Generation of induced neurons via direct conversion in vivo
PNAS, March 25, 2013
2012
Rowe H M, Kapopoulou A, Corsinotti A, Fasching L, Macfarlan TS, Tarabay Y, Viville S, Jakobsson J, Pfaff S L, Trono D
TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells
Genome Research, December 10, 2012.
Åkerblom M, Sachdeva R, Barde I, Verp S, Gentner B, Trono D, Jakobsson J
MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant
Journal of Neuroscience. 27 June 2012, Volume 32, Issue 26, pp 8879 to 8889
Åkerblom M, Sachdeva R, Jakobsson J
Functional studies of microRNAs in neural stem cells: problems and perspectives
Frontiers in neurogenesis. 07 February 2012.
2011
Quenneville S, Verde G, Corsinotti A, Kapopoulou A, Jakobsson J, Offner S, Baglivo I, Pedone PV, Grimaldi G, Riccio A, Trono D.
In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions.
Mol Cell. 2011 Nov 4;44(3):361-72.
Grealish S, Jakobsson J, Parmar M.
Lineage reprogramming : A shortcut to generating functional neurons from fibroblasts.
Cell Cycle. 2011 Oct 15;10(20):3421-2
Parmar M, Jakobsson J
Turning skin into dopamine neurons
Cell Research, online publication 9 August 2011
Pfisterer U, Kirkeby A, Torper O, Wood J, Nelander J, Dufour A, Björklund A, Lindvall O, Jakobsson J, Parmar M.
Direct conversion of human fibroblasts to dopaminergic neurons.
Proc Natl Acad Sci U S A. 2011 Jun 6.
Kirkeby A, Parmar M, Jakobsson J
Using endogenous microRNA expression patterns to visualize neural differentiation of human pluripotent stem cells
Methods in Molecular Biology, 2011 Jul 30.
2010
Sachdeva R, Jönsson M, Nelander J, Kirkeby A, Gentner B, Naldini L, Björklund A, Parmar M and Jakobsson J.
Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors.
PNAS 2010 Jun 22;107(25):11602-7.
Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T, Maillard PV, Layard-Liesching H, Verp S, Marquis J, Spitz F, Constam DB, Trono D.
KAP1 controls endogenous retroviruses in embryonic stem cells.
Nature 2010 463:237-40
2009
Tolstrup Nielsen T, Jakobsson J, Rosenqvist N and Lundberg C.
Incorporating double copies of a chromatin insulator into lentiviral vectors results in less lentiviral integrants.
BMC Biotechnology, 2009 9:13
2008
Jakobsson J, Cordero MI, Bisaz R, Busskamp V, Bensadoun JC, Cammas F, Losson R, Mansuy IM, Sandi C and Trono D.
KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress.
Neuron, 2008 60:818-31
Lundberg C, Björklund T, Carlsson T, Jakobsson J, Hantraye P, Déglon N and Kirik D.
Applications of lentiviral vectors for biology and gene therapy of neurological disorders.
Current Gene Therapy, 2008 8:461-73
2007
Wiznerowicz M, Jakobsson J, Szulc J, Liao S, Quazzola A, Beermann F, Aebischer P and Trono D.
The Kruppel-associated box repressor domain can trigger de novo promoter methylation during mouse early embryogenesis.
Journal of Biological Chemistry, 2007 282:34535-4
2006
Jakobsson J, Rosenqvist N, Marild K, V Agoston D and Lundberg C.
Evidence for disease-regulated transgene expression in the brain with the use of lentiviral vectors.
Journal of Neuroscience Research 2006 84 :58-67
Jakobsson J and Lundberg C.
Lentiviral vectors for use in the central nervous system.
Molecular Therapy 2006 13:484-93
Jakobsson J, Tolstrup Nielsen T, Staflin K, Georgievska B and Lundberg C.
Efficient transduction of neurons using Ross River glycoprotein pseudotyped lentiviral vectors.
Gene Therapy 2006 13:966-73
2005
Rosenqvist N, Jakobsson J and Lundberg C.
Inhibition of chromatin condensation prevents transgene silencing in a neural progenitor cell line transplanted to the rat brain.
Cell Transplantation 2005 14:129-38
2004
Georgievska B, Jakobsson J, Persson E, Ericson C, Kirik D and Lundberg C.
Regulated delivery of GDNF in the rat striatum using a tetracycline-dependent lentiviral vector.
Human Gene Therapy 2004 15:934-44
Jakobsson J, Rosenqvist N, Thompson L, Barraud P and Lundberg C.
Dynamics of transgene expression in a neural stem cell line transduced with lentiviral vectors incorporating the cHS4-insulator.
Experimental Cell Research 2004 298 : 611-23
Jakobsson J, Georgievska B, Ericson C and Lundberg C (2004)
Lesion-dependent regulation of transgene expression using a human glial fibrillary acidic protein-lentiviral vector.
European Journal of Neuroscience 2004 19:761-5
2003
Jakobsson J, Ericson C, Jansson M, Bjork E and Lundberg C.
Targeted transgene expression in the rat brain using lentiviral vectors.
Journal of Neuroscience Research 2003 73:876-85
Jakobsson J, Ericson C, Rosenqvist N and Lundberg C.
Lentiviral vectors.
International Reviews in Neurobiology 2003 55:111-22